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Medicine by Alexandros G.Sfakianakis

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Peripheral positional vertigo and dizziness (PPVD)

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Τρίτη, 10 Ιανουαρίου 2017

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

Abstract

A case of Cowden syndrome (CS) is described in a 34-year-old African American female who reported a history of breast and thyroid malignancies. Clinical examination demonstrated multiple soft, white-pink papules across multiple mucosal surfaces of the oral cavity. Microscopy of the lesions revealed hyperkeratotic surface squamous epithelium with papillomatosis and acanthosis along with elongated rete processes. A genomic polymerase chain reaction direct sequencing using the patient's blood was positive for mutations of the PTEN gene typical of CS.



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